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Show More From the Kinki University School of Medicine, Osaka City University School of Medicine, and AstraZeneca, Osaka, Tokushima University School of Medicine, Tokushima, National Cancer Center, Central Hospital, and Japanese Foundation for Cancer Research, Tokyo, National Cancer Center, East Hospital, Chiba, Kanagawa Cancer Center, Yokohama, and National Shikoku Cancer Center, Matsuyama, Japan; C accutane acne These observations may resolve a longstanding clinical paradox, which is that increased rates of hormone dependent breast cancer are seen in the decade after menopause when circulating estradiol is known to decrease and become noncyclical