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These two alternatives are of course not mutually exclusive, and may well entail similar results, but probably with different degrees of generality does tamoxifen cause joint pain Alkylating agents as a class have therefore been investigated for their anti tumour activity and certain of these compounds have been widely used in anti cancer therapy although they tend to have in common a propensity to cause dose limiting toxicity to bone marrow elements and to a lesser extent the intestinal mucosa